Restricted heterogeneity of polyclonal rheumatoid factors
نویسندگان
چکیده
منابع مشابه
Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium.
RA is characterized by massive proliferation of synovial tissue, accompanying infiltration of the tissue with CD4+ T lymphocytes, and a genetic linkage to the MHC antigen HLA-DR4. Since T cells are restricted by class II MHC molecules such as DR4, this suggests a direct role for these CD4+ cells in pathogenesis. To investigate T cell receptor (TCR) usage in RA, we used oligonucleotide primers s...
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Antibody responses of the immunoglobulin E (IgE) class are regulated by a finely tuned network of cellular and molecular interactions. The differentiation of IgE B lymphocytes is controlled by antigen-specific and non-antigen-specific T helper and suppressor cells and their molecular products (1-3). The antigen-specific cellular interaction can be carried out by thymus-derived (T) cells which r...
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Association of HLA-DR4/Dw4 with rheumatoid arthritis (RA) is well established, but conflicting data exist on a possible association with the severity of the disease, including its extra-articular manifestations. In order to investigate whether a subgroup of RA is preferentially associated with DR4, HLA typing was performed in two groups of patients with severe extra-articular manifestations (Fe...
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We report that sera from healthy controls, patients with ovarian or lung cancer, and patients with rheumatoid arthritis all contain IgM polyclonal rheumatoid factors which recognize antigenic determinants on murine and to a greater extent human immunoglobulin IgG. The major part of this reactivity is directed against conserved, shared antigenic determinants present on both human and murine IgG....
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Naive T cells have the capacity to expand in a lymphopenic environment in a process called homeostatic expansion, where they gain a memory-like phenotype. Homeostatic expansion is dependent on competition for a number of factors, including growth factors and interactions with their selecting self-MHC molecules. In contrast to conventional T cells, it is unclear whether class Ib-restricted CD8+ ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1987
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780300906